HOPO Therapeutics is a privately-held, clinical-stage pharmaceutical company leveraging its world-class expertise to develop treatments for heavy metal poisoning and to pioneer novel methods for directed radioisotope delivery. The company’s orally-available flagship drug candidate HOPO-101 is a heavy metal chelating agent positioned to become the best-in-class solution for significant unmet needs in lead poisoning and other forms of heavy metal toxicity, as well as nuclear and radiological threat readiness.

HOPO-101 has been well-tolerated in an ongoing Phase 1 safety study, and has shown superior pre-clinical efficacy compared to the standard-of-care medical countermeasure. Further development of our chelating agents into new delivery platforms for medical radioisotopes has yielded a pipeline of drug candidates with class-leading properties for targeted PET imaging and radioligand therapy.

1. Are any of your drugs FDA-approved?
   No, our drug products have not been approved by the FDA, and any conclusions regarding safety or efficacy for any use or indication are based solely on preclinical studies in animal models. The FDA has granted an Investigational New Drug application for our lead drug candidate HOPO-101 and a Phase 1 clinical trial is ongoing. Full Disclaimer

2. Can you answer questions or provide medical advice about metal toxicity or chelation treatments?
   No, we cannot provide any medical advice. Questions about exposure to or toxicity from heavy metals, courses of treatment, recommended chelators, symptoms related to heavy metal contamination, or any other heath-related topics should be directed to your physician.

3. What can I do to stay informed about your progress?
   Keep an eye on our website, or join our mailing list.

4. When will you be starting clinical trials?
   The Phase 1 clinical trail evaluating safety and pharmacology of HOPO 14-1 has launched, and is being conducted by SRI International. More information is can be found at https://clinicaltrials.gov/ct2/show/NCT05628961

5. Can I sign up to participate in a clinical trial?
   We are not currently enrolling participants in any clinical trials. When we have funding and approval to begin enrolling clinical trials, we will make announcements on our website and via our mailing list - please consider signing up if you would like to be notified.

6. I still have questions - who can I contact for more information?
   Our contact information is here. We regret that due to a large volume of inquiries, it may take us some time to reply depending on the nature of your message. We need to reiterate that our products are not available for sale or distribution at this time.